Mid - Life Guard 60 caps "SupHerb"
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Mid-Life Guard complex

Oxidation constitutes part of normal food metabolism in the body and takes place as a result of the decomposition of oxygen molecules during interaction with other molecules in the body.

External factors, such as radiation, air pollution, alcohol, smoking, heavy metal toxicity, drug use (with or without prescription), infections or aerobic breathing during heavy physical exercise, accelerate the oxidation process. In each of these cases excess free radicals accumulate in the body.

Free radicals

Free oxygen radicals - reactive oxygen species (ROS) - are highly reactive molecules generated during oxidation that interfere with chemical and enzymatic processes and cause damage by attacking body cells.

These instable molecules possess an uneven number of electrons in their outer shell. By colliding with other molecules they absorb the missing electron and become stabilized.

In the process these molecules are converted to free radicals, and vice versa. As a result of this chain reaction, body cells and their membranes, as well as DNA molecules are destroyed.

It should be noted that free radical activity is not only a harmful process. Free radicals play a key role in various regular biological processes that support vital functions, such as mitochondrial respiration, activation of blood platelets and synthesis of prostaglandins. This paradox of free radical chemistry provokes a lot of interest among scientists and professionals, in particular among specialists involved in ageing processes (gerontologists) and preventive medicine.

Oxidative stress - acceleration of the ageing process

In its struggle to protect itself, the body is engaged in an ongoing biochemical fight between toxic invaders (fats, heavy metals, cigarette smoke, etc.) and the immune system. This condition leads to the destruction of enzymes, hormones, cells and tissues, and in fact to a long-lasting damage to healthy body cells and systems, resulting in accelerated ageing.

Oxidative stress is a condition in which the free radical level in the body is higher than the level of antioxidants. This condition is characterized by enormous metabolic pressure, which may lead to oxidation of fats, proteins and sugars and damage to DNA and endothelium . This process causes cellular damage and development of age-dependent diseases such as cardiovascular disease, diabetes, cancer, Alzheimer and other typical geriatric diseases

caused by oxygen free radicals

The need for antioxidants

Change of lifestyles and diet in order to increase antioxidant levels in the body is of vital importance to reduce the risk of chronic diseases and slow down the ageing process. The antioxidants produced by the body or supplied to it through food or food supplements, neutralize the destructive activity of the free radicals, enabling us to protect our body cells. In fact, the health of each individual cell in the body depends on the balance between the free radicals and antioxidants.

* Coenzyme Q-10, like other antioxidants, is capable of destroying free radicals before they cause damage, thus protecting DNA molecules, cell walls and even different enzymatic processes related to food and oxygen metabolism in the body. By reduction (reducing the oxidative state of vitamin E) coenzyme Q-10 increases the regeneration process of vitamin E and, in fact, converts it to an antioxidant with increased availability to catch free radicals before they can do any damage.

Research has shown that food supplements containing a combination of vitamin E and coenzyme Q-10 more increase the resistance of LDL to oxidation than vitamin E only .

Since LDL oxidation is thought to be the main factor in the development of arteriosclerosis, consumption of a combination of these two substances is very important for the prevention of cardiovascular disease. After addition of exogenous coenzyme Q-10, the mitochondrial vitamin E concentration reflects a sparing and regeneration effect exerted by coenzyme Q-10 on vitamin E

Coenzyme Q-10, also known as ubiquinone due to its chemical structure, is a vitamin-like antioxidant produced in the body and present in every body cell. It can also be ingested with food - it is present in foodstuffs such as sardines, anchovy, broccoli, spinach, walnuts etc. - but the average nutritional intake, 2-5 gram per day, is not sufficient. This is an important observation, particularly since coenzyme Q-10 is involved in cellular energy production, mainly in myocardial cells, where it is present in high concentration.

At the age of twenty, coenzyme Q-10 levels in the body already start to decrease. Inferior nutrition, modern lifestyle and consumption of cholesterol-lowering drugs constitute only a few of the factors that contribute to the increasing need of the body for this essential substance. Lack of substances such as folic acid, vitamin B-6, B-12 pantothenic acid, vitamin C and others, can damage synthetic processes in the body.

Most studies performed on the relationship between coenzyme Q-10 deficiency and cardiac disease found that enrichment of food with 60 to 120 mg coenzyme Q-10 powder increases coenzyme Q-10 levels to normal or to 2 to 4 times above norm. The supplement improved cardiac muscle performance, increased cardiac output, provided protection against myocardial ischemia, etc.

Coenzyme Q-10 effectively stabilizes the cell wall and has a positive effect on blood platelets. These properties of coenzyme Q-10 explain its advantages as an inhibitor of ageing processes.

The Singh group studied the effect of coenzyme Q-10 in patients suffering from acute myocardial infarct (AMI).The patients participating in the trial received supplementary coenzyme Q-10 at a dose of 120 mg daily for 28 days (n=145). The coenzyme Q-10 group showed a statistically significant improvement compared to the control group in the following parameters:

Myocardial activity: 22.5% compared to 8.2%

Cardiac rhythm: 25.31% compared to 9.5%

Angina pectoris: 28.1% compared to 9.5%

Likewise, there was a decrease in the number of deaths recorded from cardiac events in the coenzyme Q-10 group compared to the control group: 15% compared to 30.9% (8)

Studies by Kuklinski also demonstrated a decrease in the number of deaths among AMI patients as a result of combined administration of 100 mg coenzyme Q-10 and 500 mcg selenium (9).

Research on cancer also confirms the positive effect of coenzyme Q-10. In a study by Portakal, observed coenzyme Q-10 levels and enzymatic parameters indicated activity in breast cancer cells. In these cells a significant decrease in coenzyme Q-10 levels was observed compared to non-cancerous cells. Furthermore, a considerable increase in coenzyme Q-10 activity was observed. This situation of decreased levels of coenzyme Q-10 and increased enzymatic activity indicates the effort the body is making to overcome the carcinogenic activity in the cancer cells (10). Additional cancer research showed a relationship between cellular coenzyme Q-10 levels and the severity of the cancer in the body (11).

Coenzyme Q-10 has a chemical structure similar to vitamin E, and thus it is not surprising that they possess similar biochemical activity and share antioxidant effects to reduce the harm caused by free radicals.

Studies have shown that the combined administration of coenzyme Q-10 and vitamin E better protects LDL against oxidation than vitamin E alone. Since oxidation of LDL is the main factor in the development of arteriosclerosis, this finding is very important for the prevention of cardiovascular disease.

* Vitamin E
Vitamin E is a fat-soluble vitamin present in plasma, red blood cells and different tissues. It plays a central role in keeping biological membranes intact. It is thought that vitamin E is the most important antioxidant attacking free radicals, to prevent the havoc they wreak on tissues of organs that are most susceptible to oxidation - heart, blood vessels, brain, skin and the hormonal system. Its crowning achievement is the prevention of the oxidation of LDL, so that plaque formation on the vessel walls, otherwise known as arteriosclerosis, is prevented.

There is a distinct difference between the effects of natural vitamin E - d-alpha-tocopherol - or the recommended water-soluble form - d-alpha-tocopheryl succinate - and the synthetic form - dl-alpha-tocopheryl acetate. Studies have shown that natural vitamin E is more effective than its synthetic form in the prevention of age-dependent diseases such as cardiovascular disease, diabetes, Alzheimer, etc .

Epidemiological studies on chronic administration of vitamin E unambiguously demonstrated the efficacy of vitamin E in the prevention of cardiac disease. The Nurses Health Study observed a significant difference in risk level between a group of women in the high percentile of vitamin E consumption compared to the group in the low percentile - 0.87 compared to 0.50 (13).

A similar decrease was observed in the Health professionals` Follow-up study (21). In the study of Knokt et al. a reverse relation was reported between the consumption of vitamin E and the number of deaths from cardiac disease (15). Such a relationship was also found in the Iowa Women`s Study (16).

As antioxidant, vitamin E acts synergistically with other antioxidants such as selenium, beta-carotene, co-enzyme Q-10 and vitamin C. Studies exploring the relationship between vitamin E and coenzyme Q-10 showed that vitamin E helps to increase the intracellular level of coenzyme Q-10. The accepted hypothesis assumes the existence of a common mechanism for the penetration of coenzyme Q-10 and vitamin E into the cell.

* Selenium
Selenium is an antioxidant mineral acting jointly with vitamin E. It is essential for proper development and growth of the body. This trace element was discovered in 1916, but its significance and function remained unknown until 1953, when it was discovered that selenium is capable of preventing cellular damage caused by vitamin E deficiency. Further studies conducted over the years proved that combined lack of selenium and vitamin E causes the development of certain diseases.

In a study conducted in laboratory animals it was found that the organs most affected by the lack of these two essential antioxidants were cardiac muscle, erythrocytes, eyes, liver, kidneys, pancreas, skeletal muscle, smooth muscles, skin cells and sperm cells.

The combined lack of vitamin E and selenium worsens the damage caused by oxidative stress of the muscles. This deterioration destroys the skeletal muscles, which impairs mobility and the ability to eat and breath, resulting in the death of the animal.

Legend: Extent of injury caused by oxidative stress as a result of combined selenium and vitamin E deficiency
Persons suffering from a lack of selenium are at a higher risk of getting cancer, and in certain cases even of AIDS, due to the key role selenium plays in keeping the immune system intact. This is expressed in various viral diseases and in its ability to repair cellular damage, as well as in the prevention of carcinogenic mutations (15, 16).
Many studies have proven the direct relationship between soil lacking selenium and a high rate of different cancers in the population. It is important to note that 21st century food is short of this mineral because our food is grown on selenium-poor soil.

Selenium also acts to prevent the oxidation of LDL-cholesterol and, therefore, of cardiac disease. In addition, selenium is essential for the formation of one of the most important antioxidants - glutathione peroxidase -, which offsets free radicals and especially those that attack fat molecules, and for detoxification processes, i.e., elimination of toxic substances from the body.
It is known that selenium acts synergistically with vitamin E, and studies have shown that it is capable of preventing cellular damage caused by vitamin E deficiency.

The recommended daily allowance of selenium for the prevention of deficiency symptoms is 55-75 mcg. At higher levels the importance of selenium as antioxidant for the prevention of cardiac disease and cancer becomes apparent (16). At a dose of 300 mcg, selenium proved to be an effective antioxidant (19).

Studies measuring the combined effect of food supplements showed that the best protection was found when fatty antioxidants, such as vitamin E, selenium and coenzyme Q-10, were combined with non-fatty ones, like vitamin C and beta-carotene .

The advantage of combining

Each of the above mentioned antioxidants- coenzyme Q-10, vitamin E and selenium- contributes in its own specific way to the protection against oxidative stress. Moreover, a synergistic effect reinforces the biological action of the three compounds.

Studies have shown that a combination of coenzyme Q-10, vitamin E and selenium is more effective and has a broader spectrum of protective action against a variety of oxidative factors than each supplement individually.

Ultimate protection against oxidative stress

Mid-Life Guard series is a novel food supplement, developed and produced exclusively by SupHerb, whose formulation is based on extensive research and treatment results with these supplements.

Mid-Life Guard provides extensive protection against the dangers inherent to high levels of free radicals in the body. This formulation offers an optimal combination of the three antioxidants - coenzyme Q-10, vitamin E and selenium -, providing more extensive protection against a broader spectrum of oxidative factors than consumption of each of the supplements individually.

Ultimate protection against oxidative stress

Mid-Life Guard of SupHerb`s Nutrition series is a novel food supplement, developed and produced exclusively by SupHerb, whose formulation is based on extensive research and treatment results with these supplements.

Mid-Life Guard provides extensive protection against the dangers inherent to high levels of free radicals in the body. This formulation offers an optimal combination of the three antioxidants - coenzyme Q-10, vitamin E and selenium -, providing more extensive protection against a broader spectrum of oxidative factors than consumption of each of the supplements individually.

Recommended dosage: 1-2 capsules daily, to be taken with a meal

Mid-Life Guard series is available in packages of  60 capsules

Contents:
Each vegetable capsule Vcaps of Mid-Life Guard series contains:
Coenzyme Q-10................................................................60 mg
Vitamin E (d-alpha tocopheryl succinate).............................200 IU
Selenium .........................................................................100 mcg
(L-Selenomethionine 500 mcg which provide 100 mcg Selenium)

• Barcode: 7290001697566
• Shipping Weight: 0.16kg
• Manufactured by: SupHerb - Natural Food Supplements

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